Protective genotypes in HIV infection reflect superior function of KIR3DS1 + over KIR3DL1 + CD8 + T cells
نویسندگان
چکیده
منابع مشابه
Protective genotypes in HIV infection reflect superior function of KIR3DS1+ over KIR3DL1+ CD8+ T cells
Certain human class I histocompatibility-linked leukocyte antigen (HLA)/killer cell immunoglobulin-like receptor (KIR) genotypic combinations confer more favourable prognoses upon exposure to human immunodeficiency virus (HIV). These combinations influence natural killer (NK) cell function, thereby implicating NK cells in protection from HIV infection or disease progression. Because CD8(+) T ce...
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Natural killer (NK) cells play a role in the clearance of viral infections. Combinations of alleles at the polymorphic HLA-B locus and the NK cell surface killer immunoglobulin-like receptor locus KIR3DL1/S1 have been shown to influence time to AIDS in HIV-infected individuals and risk of seroconversion in HIV exposed seronegative (HESN) subjects. Here, we assessed time to seroconversion or dur...
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ژورنال
عنوان ژورنال: Immunology & Cell Biology
سال: 2014
ISSN: 0818-9641,1440-1711
DOI: 10.1038/icb.2014.68